Последние направления в лечении ВИЧ

Интересная обзорная статья в бесплатном доступе.

http://www.biomedcentral.com/1741-7015/13/284

Клопидогрель и аспирин при постоперационной мигрени

Вот тут описывают, что клопидогрель в комбинации с аспирином эффективнее чем аспирин в монотерапии уменьшает частоту и (значительно) интенсивность мигренозных приступов после кардиохирургического вмешательства.

Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure

Importance  The occurrence of new-onset migraine attacks is a complication of transcatheter atrial septal defect (ASD) closure. It has been suggested that clopidogrel may reduce migraine attacks after ASD closure.

Objective  To assess the efficacy of clopidogrel, used in addition to taking aspirin, for the prevention of migraine attacks following ASD closure.

Design, Setting, and Participants  Randomized, double-blind clinical trial performed in 6 university hospitals in Canada. Participants were 171 patients with an indication for ASD closure and no history of migraine.

Interventions  Patients were randomized (1:1) to receive dual antiplatelet therapy (aspirin + clopidogrel [the clopidogrel group], n = 84) vs single antiplatelet therapy (aspirin + placebo [the placebo group], n = 87) for 3 months following transcatheter ASD closure. The first patient was enrolled in December 2008, and the last follow-up was completed in February 2015.

Main Outcomes and Measures  The primary efficacy outcome was the monthly number of migraine days within the 3 months following ASD closure in the entire study population. The incidence and severity of new-onset migraine attacks, as evaluated by the Migraine Disability Assessment questionnaire, were prespecified secondary end points. A zero-inflated Poisson regression model was used for data analysis.

Results  The mean (SD) age of the participants was 49 (15) years and 62% (106) were women. Patients in the clopidogrel group had a reduced mean (SD) number of monthly migraine days within the 3 months following the procedure (0.4 [95% CI, 0.07 to 0.69] days) vs the placebo group (1.4 [95% CI, 0.54 to 2.26] days; difference, −1.02 days [95% CI, −1.94 to −0.10 days]; incident risk ratio [IRR], 0.61 [95% CI, 0.41 to 0.91]; P = .04) and a lower incidence of migraine attacks following ASD closure (9.5% for the clopidogrel group vs 21.8% for the placebo group; difference, −12.3% [95% CI, −23% to −1.6%]; odds ratio [OR], 0.38 [95% CI, 0.15 to 0.89]; P = .03). Among patients with migraines, those in the clopidogrel group had less-severe migraine attacks (zero patients with moderately or severely disabling migraine attacks vs 37% [7 patients] in the placebo group; difference, −36.8% [95% CI, −58.5% to −15.2%]; P = .046). There were no between-group differences in the rate of patients with at least 1 adverse event (16.7% [14 patients] in the clopidogrel group vs 21.8% [19 patients] in the placebo group; difference, −5.2% [95% CI, −17% to 6.6%]; P = .44).

Conclusions and Relevance  Among patients who underwent transcatheter ASD closure, the use of clopidogrel and aspirin, compared with aspirin alone, resulted in a lower monthly frequency of migraine attacks over 3 months. Further studies are needed to assess generalizability and durability of this effect.

Trial Registration  clinicaltrials.gov Identifier:NCT00799045

This randomized trial of patients who had no history of migraines compared incidence of migraine attacks between those who used aspirin plus clopidogrel vs aspirin plus placebo for 3 months after undergoing transcatheter atrial septal defect closure.

Ссылка на pdf: http://jama.jamanetwork.com/data/Journals/JAMA/0/joi150131.pdf

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